Technological University Dublin

The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin

Dublin Institute of Technology

Fiona Lyng

John O'Leary

Damien Traynor

Lisa White

Padraig Kearney

Isabel Vega Carrascal

Cara Martin

Orla Howe

Adrian Maguire

Shiyamala Duraipandian

Aidan Meade

Franck Bonner

The present invention provides a method of using Raman spectroscopy for identification of low grade cervical cytology cases likely to progress to high grade/cancer. The Applicant has found that high quality Raman spectra can be successfully acquired from morphologically normal appearing cells from negative, LSIL and HSIL Thinprep&#xae; specimens and different grades of cervical pre-cancer can be separated with good sensitivities and specificities. Raman spectroscopy can further identify different categories of the LSIL cases i.e., whether they are likely to regress to negative or progress to HSIL cytology.

Method for identification of low grade cervical cytology cases likely to progress to high grade/cancer

The invention relates to a prognostic method of analyzing a biological sample from a cancer patient to predict his/her response to a specified modality of cancer treatment comprising the steps of: (a) performing spectroscopy on the biological sample to obtain a spectrum; (b) comparing the obtained spectrum with one or more spectra to calculate a probability of a response to the specified modality of cancer treatment by the cancer patient.

Prediction of therapeutic response using vibrational spectroscopy

Growing community of inventors

Dublin, Ireland

Fiona Lyng