Drug Delivery International Limited

Fiona Jane Macdougall

Alexander Balfour Mullen

Howard Norman Ernest Stevens

David Smith

Vivekanand Bhardwaj

Claire Helen Ordoyno

A method for making a controlled release material, comprising the steps of: &#x2014; (a) forming granules comprising one or more wax and one or more disintegrant; (b) spheronisation of the granules and (c) compaction of the spheronised granules of step so as to form the controlled release material. The invention also relates to a tablet and delayed and sustained release material made according to the method.

Pharmaceutical processing

A press coated tablet for delayed release of an active ingredient comprising: (a) a core comprising one or more active ingredients, and; (b) an erodible delayed release barrier surrounding the core and comprising a wax and two or more grades of L-HPC, wherein the wax and L-HPC are provided in a weight ratio of wax to L-HPC of from 30%:70% to 70%:30%. The invention also relates to a method of making the press coated tablet.

Press coated tablet prepared for delayed release of an active ingredient

A method of forming an erodible sustained release tablet comprising the steps of:&#x2014;a. mixing one or more therapeutic agents, one or more disintegrant and one or more molten wax, whilst retaining the wax in molten form; b. solidifying and granulating the mixture; c. forming a tablet by compression of the granules. The invention also relates to a sustained release tablet made according to the method.

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Strathclyde, United Kingdom

Fiona Jane Macdougall