Akzona Incorporated

Merck Patent Gesellschaft MIT Beschrankter Haftung

Akzo N.v.

Filippus J Zeelen

Marinus B Groen

Manfred Baumgarth

Dieter Orth

Hans-Eckart Radunz

Reinhard Lissner

Hans-Joachim Enenkel

David S Savage

Thomas Sleigh

Colin L Hewett

Alexander C Campbell

Arnoldus I Broess

New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein:

Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives

New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein:

Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series

The invention relates to novel compounds of general formula I: ##STR1## and salts, esters and amides thereof, in which R.sub.1 and R.sub.2 represent hydrogen, alkyl or alkenyl (1-4 C),

Di-Carboxylic acid derivatives

There are disclosed substrates of the formula: ##STR1## wherein: (a) R.sub.1 is H or C.sub.1 -C.sub.4 alkyl;

Cyclization substrates, cyclization process and related

Cyclisation substrates are disclosed of the formula: ##STR1## wherein: (a) R.sub.1 is H or alkyl of one to four carbon atoms;

Cyclization substrates and related 11.alpha.-equatorially-substituted

Novel cyclization substrates of the formula: ##STR1## wherein: (a) R.sub.1 is H or alkyl of one to four carbons;

Cyclization substrates and 6.alpha.-substituted 19-norsteroid derivatives

Novel cyclization substrates are disclosed of the formula ##STR1## wherein: (a) R.sub.1 is H or alkyl of one to four carbon atoms;

Cyclization substrates and 7.alpha.-substituted 19-norsteroid derivatives

Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl of 1-4 carbon atoms;

Prostenoic acid derivatives

Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl or 1-4 carbon atoms;

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Heesch, Netherlands

Filippus J Zeelen