Olon S.p.a.

Filippo Nisic

Stefano Maiorana

Giorgio Bertolini

Corrado Colli

Aldo Bianchi

Silvano Ronzoni

Mara Sada

Federica Colombo

Romano Di Fabio

Stefania Bertuolo

Lazzaro Feliciani

Federico Gassa

Faris Garis

Paolangelo Cerea

Cinzia Biaggi

Adolfo Prandi

Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.

Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates

The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.

Process for the preparation of a novel umeclidinium synthesis intermediate

Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I): 

Process for the preparation of indanamine derivatives and new synthesis intermediates

The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.

Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters

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Milan, Italy

Filippo Nisic