Chiron Corporation

Novartis Vaccines & Diagnostics, Gmbh

Nuvelo, Inc.

Filippo M Randazzo

Giulia C Kennedy

Christoph Reinhard

Jaime A Escobedo

Pablo Dominguez Garcia

George Lamson

Julie Sudduth-Klinger

Radoje Drmanac

Lewis T Williams

Snezana Drmanac

Michael A Innis

Klaus Giese

David B Kita

Joerg Kaufmann

Vivien W Chan

David Pot

Ivan Labat

Altaf Kassam

Rhonda Hansen

Birgit Stache-Crain

Radomir Crkvenjakov

Mark Dickson

Dena Leshkowitz

Edward J Moler

Veronica Garcia

Lee William Jones

The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

Gene products differentially expressed in cancerous cells

This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

Human genes and gene expression products V

Human genes and gene expression products II

A human tumor suppressor gene termed polyhomeotic 2 and its expression products can be used as therapeutic, prognostic, and diagnostic tools for proliferative and developmental disorders. Nucleotide sequences of the gene can also be used to identify a p34.3 region of a human chromosome 1.

Human polyhomeotic 2 (hph2) acts as a tumor suppressor

A human oncogene and its expression products can be used as diagnostic, prognostic, and therapeutic tools for neoplastic disorders. Nucleotide sequences of the gene can also be used to identify a p34.3 region of a human chromosome 1.

Human polyhomeotic 2 (hph2) acts as an oncogene

Mammalian deep orange tumor suppressor genes are disclosed. Mammalian deep orange genes and proteins can be used as therapeutics, as diagnostic tools, and in making animal models. The genes can be used to identify a q13 region of a human chromosome 15 and a central region of a mouse chromosome 2.

Mammalian deep orange proteins

A novel human oncogene termed polyhomeotic 1 is disclosed. The human polyhomeotic 1 gene and protein can be used, inter alia, as a diagnostic tool for neoplastic disorders. The gene can also be used to identify a p13 region of human chromosome 12.

Human polyhomeotic 1(HPH1) acts as an oncogene

Mammalian deep orange nucleotides

Mammalian Asx gene and amino acid sequences encoded by the mammalian Asx gene, are described. The mammalian Asx gene and gene products are useful for diagnostic and therapeutic applications in proliferative and developmental disorders. Modulators of mammalian Asx can be identified using the disclosed genes. The modulators can be used in the context of cancer therapy or a treatment of a developmental disorder. Asx is also useful for inducing differentiation in a population of progenitor cells.

Mammalian additional sex combs (mammalian Asx) acts as a tumor suppressor

Mammalian Scm gene and amino acid sequences encoded by the mammalian Scm gene, are described. The mammalian Scm gene and gene products are useful for diagnostic and therapeutic applications in proliferative and developmental disorders. Modulators of mammalian Scm can be identified using the dislcosed genes. The modulators can be used in the context of cancer therapy or a treatment of a developmental disorder. Scm is also useful for inducing differentiation in a population of progenitor cells.

Mammallian sex comb on midleg (mammalian SCM) acts as a tumor suppressor

Growing community of inventors

Emeryville, CA, United States of America

Filippo M Randazzo