Beth Israel Deaconess Medical Center, Inc.

Ffolliott Martin Fisher

Eleftheria Maratos-Flier

Mark A Herman

Jody Dushay

The invention provides, inter alia, methods of monitoring the fructose response of a subject by determining the level of fibroblast growth factor 21 (FGF21) gene expression product in a biological sample (such as a serum sample) from the subject, where the subject was previously administered a fructose bolus. The invention also provides methods of monitoring the response of a subject to a treatment for a disorder of metabolism, for discriminating fructose intolerance from other gastrointestinal disorders not associated with fructose intolerance, for identifying a subject at risk for developing a disorder of metabolism, as well as methods of treatment for a disorder of metabolism.

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Watertown, MA, United States of America

Ffolliott Martin Fisher