Harvard College

Feruz Ganikhanov

Xiaoliang Sunney Xie

Conor L Evans

Francois Légaré

Connor Evans

A system is disclosed for detecting a signal field from a sample volume. The system includes a source system and an optical fiber system. The source system provides a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency. The optical fiber system includes at least one optical fiber for guiding the first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume. The optical fiber system also receives the signal field resulting from the coherent radiation, and guides the signal field to a detector.

System and method for coherent anti-Stokes Raman scattering endoscopy

A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first electromagnetic field at a first frequency &#x3c9;and a second electromagnetic field at a second frequency &#x3c9;toward a focal volume such that a difference frequency &#x3c9;&#x2013;&#x3c9;is resonant with a vibrational frequency of a sample in the focal volume. The modulation system is for modulating the difference frequency &#x3c9;&#x2013;&#x3c9;such that the difference frequency &#x3c9;&#x2013;&#x3c9;is tuned in and out of the vibrational frequency of the sample of at a modulation frequency. The detector system is for detecting an optical field that is generated through non-linear interaction of &#x3c9;and &#x3c9;and the sample responsive to the modulation frequency.

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Annandale, NJ, United States of America

Feruz Ganikhanov