Danisco US Inc.

Genencor International, Inc.

E.i. Dupont De Nemours and Company

Codexis, Inc.

The Goodyear & Tire Rubber Company

Genomatica, Inc.

Reg Life Sciences, LLC

Ls9, Inc.

E.p.i. Liquidation Co.

Danisco A/s, Genencor Division

Danisco US In.

Genecor International, Inc.

Microgenomics, Inc.

Fernando Valle

Marguerite A Cervin

Gregory Marshall Whited

Joseph Charles McAuliffe

Philippe Soucaille

Frank James Feher

Aaron Scott Puhala

Gopal K Chotani

Karl John Sanford

Andrei Miasnikov

Louis Clark

M Harunur Rashid

Donald Eugene Trimbur

Mark Scott Payne

Manoj N Kumar

Jonathan Vroom

Robert Mark Caldwell

Zhihao Hu

Caroline M Peres

Ramesh V Nair

Richard La Duca

Timothy C Dodge

Robert G McDaniel

Stephen K Picataggio

Behnaz Behrouzian

Carol Marie Fioresi

James A Hoch

Douglas A Hattendorf

Kristian Karlshoej

Veronique A Dartois

Kaman Chan

Yoram Barak

Ilana S Aldor

Nigel S Dunn-Coleman

Robert Osborne

Eugenio Ferrari

Anthony Arthur Gatenby

Catherine M Cho

Amy Kuang-Hsu

Svetlana Balatskaya

Patricia Choudhary

Jovana Nazor

Stephen B Del Cardayre

Fernando A Sanchez-Riera

Claus M Krebber

Smita Shankar

Kenneth W Mitchell

Yihui Zhu

Fernando Sanchez-Riera

Monica Bhatia

Trish Choudhary

Amy Kuang-Hua Hsu

U Loi Lao

Saul Nitsche Rocha

Amy K Hsu

Phillipe Soucaille

Joseph C Mcauliffe

Robert Mcdaniel

Harunur M Rashid

Ramesh Nair

Manoj Kumar

Timothy G Dodge

Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.

Production of fatty acid esters

Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

Recombinantfor enhanced production of fatty acid derivatives

The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.

Compositions and methods for producing isoprene

Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.

Enhanced production of fatty acid derivatives

The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase ('FAR'); a gene encoding a heterologous thioesterase ('TE') gene and a gene encoding an acyl-CoA synthetase (&#x201c;ACS&#x201d;).

Production of fatty alcohols from engineered microorganisms

The present invention provides compositions and methods comprising a low-phosphate repressible promoter. In particular, the present invention provides a low-phosphate repressible promoter from

Low-phosphate repressible promoter

Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a &#x3b2;-ketoacyl acyl carrier protein synthase.

The present invention relates to a method of creating DNA libraries that include an artificial promoter library and/or a modified ribosome binding site library and transforming bacterial host cells with the library to obtain a population of bacterial clones having a range of expression levels for a chromosomal gene of interest.

Method of creating a library of bacterial clones with varying levels of gene expression

Genetically engineered cells and microorganisms are provided that produce fatty alcohols and fatty acids. In particular, engineered microbial cells comprise a modified native gene having &#x3b2;-ketoacyl-acp synthase activity.

Modified native beta-ketoacyl-ACP synthases and engineered microorganisms

The present invention provides host cells having improved sugar utilization or co-utilization, methods of producing host cells having improved sugar utilization or co-utilization, and methods of using host cells having improved sugar utilization or co-utilization. The present invention providesstrains that co-utilize glucose and xylose in the presence of glucose and xylose, wherein the cell produces the product.

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Recombinant bacterial microorganisms are provided which comprise heterologous fatty acyl reductases ('FAR') polypeptides wherein said microorganisms have been engineered to produce increased amounts of saturated fatty alcohols and methods of making saturated fatty alcohols using the recombinant bacterial microorganisms.

Production of saturated fatty alcohols from engineered microorganisms

It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has &#x3b4;C value of greater than &#x2212;22%.

Polymers of isoprene from renewable resources

Genetically engineered microorganisms that produce fatty alcohols from a sugar source by way of the fatty acid biosynthetic pathway, as well as methods of their use are provided.

Growing community of inventors

Burlingame, CA, United States of America

Fernando Valle