Universidad Del País Vasco

Dominion Pharmakine S.l

Fernando Pedro Cossio

Aizpea Zubia Olascoaga

Miren Lorea Mendoza Arteche

Fernando Vidal Vanaclocha

Silvia Vivanco Amato

Eneko Aldaba Arévalo

María Valcárcel Cuesta

Yosu Ion Vara Salazar

Natalia Gallot Escobal

Eneko Aldaba Arevalo

Clarisa Salado Pogonza

Yosu Ion Vara Salazr

This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof

This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also relates to the administration of compounds of the invention as agents for the treatment of mammalian diseases whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable cellular and molecular activities or responses induced by integrin-dependent molecular interactions.

Derivatives of nitroproline compounds, processes of manufacture and uses in the treatment of integrin mediated disorders

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Leioa, Spain

Fernando Pedro Cossio