Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Fernando Padilla

Chris Richard Melville

Xiaoming Zhang

Cyrus K Becker

Jürg Roland Pfister

Joan Marie Caroon

Counde O'Yang

Francisco Javier Lopez-Tapia

Jim W Li

Terrence Joseph Connolly

Klaus K Weinhardt

Dov Nitzan

Paul Francis Keitz

Eun Kyung Lee

Patrick Finbar McGarry

Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', Rand Rare as defined herein.

Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists

This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: 

Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists

This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I:wherein Z is &#x2014;C(O)&#x2014; or &#x2014;S(O)&#x2014;, X is carbon or nitrogen, Y is carbon, and X&#x2014;Y considered together are two adjoining atoms of the ring A, said ring being a fused aromatic ring of five to six atoms per ring optionally incorporating one to two heteroatoms per ring, chosen from N, O, or S; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

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Fremont, CA, United States of America

Fernando Padilla