Centre National De La Recherche Scientifique

Universitë De Bordeaux

Guerbet

Université De Bordeaux 1

Fernando Leal Calderon

Marc Port

Caroline Robic

Serge Ravaine

Véronique Schmitt

J&eacute;r&ocirc;me Bibette

Lida Bonnakdar

Marie-Fran&ccedil;oise Ficheux

Jer&ocirc;me Bibette

Samy Chadel

Florence Guimberteau

Jérôme Michel Jaques Bibette

Philippe Gorria

Stéphane Résidence Campus Haut Brion Reculusa

Jerome Michel Bibette

Stéphane Résidence Villebon Arditty

Joanna Kahn

The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising:

Chelate nanoemulsion for MRI

A fractionable polydisperse stable double oil-in-water emulsion, having 50 to 95 wt. % relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase. The continuous aqueous phase includes a polysaccharide thickening agent in a proportion of 1 to 10 wt. % relative to the total weight of the continuous aqueous phase, a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant, and an osmotic pressure balancing agent. The emulsion Ei has a viscosity not higher than the viscosity of the continuous aqueous phase and has 50 to 95 wt. %, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase. The internal aqueous phase includes an active hydrophilic substance and the oily phase includes poly glycerol polyricinoleate as surfactant.

Polydisperse double emulsion, corresponding monodisperse double emulsion and method for preparing the monodisperse emulsion

A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.

Method for releasing an active principle contained a multiple emulsion

A process provides a stable emulsion, in particularly a stable, concentrated bitumen emulsion, by emulsifying a first hydrophobic or hydrophilic phase having a viscosity between 1 and 5000 Pa.s with a second phase immiscible in the first phase, in the presence of at least one surfactant, by mixing together the first phase, second phase, and surfactant under a laminar shear regime.

Method for preparing concentrated and emulsions calibrated in a highly viscous phase, in particular bitumen emulsions

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La Brede, France

Fernando Leal Calderon