Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Fernando Giuliani

Sergio Penco

Alberto Bargiotti

Antonino Suarato

Michele Caruso

Francesco Angelucci

Maria Grandi

Pierangelo Zini

Mauro Gigli

Antitumour anthracycline glycosides of formula I: ##STR1## wherein R.sub.1 is hydrogen or a hydroxyl group, and pharmaceutically acceptable acid addition salts thereof.

4-demethoxy-4'-amino-4'-deoxy-anthracycline derivatives

Anthracycline glycosides of the general formula (A'): ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R.sub.2 and R.sub.3 represents a hydroxy group and the other of R.sub.2 and R.sub.3 represents a nitro group; and R.sub.4 represents a hydrogen atom or a hydroxy group; and their pharmaceutically acceptable salts; have anti-tumor activity.

Nitro anthracyclines, process for their preparation and use thereof

Anthracycline glycosides of general formula (I) ##STR1## wherein R is hydrogen or hydroxy, and pharmaceutically acceptable salts thereof, are anti-tumor agents.

3'-deamino-3'-hydroxy-4'-deoxy-4'-amino doxorubicin and related

Anthracycline glycosides of the general formula (A): ##STR1## wherein X is hydrogen or hydroxy and R is hydrogen or a methyl or a hydroxymethyl group; and their pharmaceutically acceptable salts; are useful as antitumor agents.

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Cassina De Pecchi, Italy

Fernando Giuliani