Hepar Chimie S.a.

Other

Hepar Industries, Inc.

Fernando Fussi

Gianfranco Fedeli

A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.

Oligo-heteropolysaccharides having a heparin-like activity method for

The present invention relates to a process for obtaining low molecular weight heparins endowed with pharmacological and therapeutic properties of outstanding interest, starting from normal heparin. The said process is characterized in that it comprises the following steps:

Process for obtaining low molecular weight heparins endowed with

Natural heteropolysaccharide, specifically hexuronyl hexosaminoglycane sulfate and, a process to obtain it, which substantially provides for the following steps:

Natural hexuronyl hexosaminoglycane sulfate, method for the preparation

Hexuronyl hexosaminoglycane sulfate and related therapeutical uses

From the residual liquors of the extraction of active principles, particularly heparin, from animal organs, a fraction of natural polyanions is obtained having, besides clearing and anticoagulant activity, also antiphlogistic and anti-inflammatory activity as well as stimulating activity on the reticuloendothelial system, whereby it is useful in the treatment of atherosclerosis and related diseases. The process for obtaining these natural polyanions is also disclosed.

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Lesmo, Italy

Fernando Fussi