Instituto Biomar, S.a.

Fernando Espliego

Francisco Romero

Dolores Garcia Gravalos

Julia Perez-Baz

Librada Maria Cañedo

Jose Luis Fernandez-Puentes

Librada Maria Canedo

Librada Maria Ca&ntilde;edo

Julia Perez

Rosa Isabel Fernandez-Chimeno

The invention provides compounds of formula (1) wherein Ris a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and Ris a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.

Indolocarbazole alkaloids from a marine actinomycete

A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R and R can be hydrogen, alkyl, or together R and R form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Polycylic xanthones and their use

The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.

Macrolides with antitumor activity

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Leon, Spain

Fernando Espliego