Nioxx LLC

Ferid Murad

Alexandru T Balaban

William A Seitz

Cheng-Shing Chen

William J Merrell

Kenneth A Smith

Kenneth James Smith

Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form.

Extended production of nitric oxide from a microencapsulated nitrite salt and an aqueous acidified gel

Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of water-soluble chemical reactants microencapsulated in polymer matrices. In some applications the microencapsulated reactants are introduced in an aqueous gel, and in other applications they are introduced to the area of therapy either directly or in a medical device such as a therapeutic pad or dressing. In some applications, the microencapsulated chemical precursors are maintained in close physical proximity to one another in a limited volume, and using a limited amount of solvent residing within that same volume to extract and process the chemical precursors to form NO.

Extended production of nitric oxide from microencapsulated chemical reactants

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McLean, VA, United States of America

Ferid Murad