Egis Gyogyszergyar

Richter Gedeon Vegyeszeti Gyar Rt

Eotvos Lorand Tudomanyegyetem

Ferenc Szederkenyi

Imre Moravcsik

Gabor Kovacs

Antal Simay

Kalman Nagy

Zoltan Zubovics

Gyorgy Krasznai

Lajos Toldi

Eva Kovacs Nee Bozo

Gyorgyi Vereczkey Nee Donath

Gabor Feher

Gyula Horvath

Gabor Ambrus

Istvan Gebhardt

Eva Ilkoy

Antonia Jekkel

Istvan Pallagi

Nandor Makk

Kalman Konczol

Andras Toro

Dezso Knausz

Zsuzsanna Kolos

Janos Rohonczy

Janos Volford

B',acu/e/ La Csakvari

Aranka Meszticzky

Kamtan Ujszaszy

The invention relates to a novel process for the preparation of 17 .alpha.-hydroxy-20-oxopregnane derivatives of the general formula (I), ##STR1## wherein R.sub.1 means a hydroxy or an oxo group; and

Process for the preparation of steroids bearing

The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) ##STR1## which comprises reacting an ester of the general Formula (X) ##STR2## wherein X represents halogen and Z stands for a straight or branched chain C.sub.1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group--with an alkali salt of 2,5-dimethylphenol of Formula (II) ##STR3## or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. ##STR4## Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.

Process for the preparation of

The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) ##STR1## which comprises reacting an ester of the general Formula (X) ##STR2## wherein X represents halogen and Z stands for a straight or branched chain C.sub.1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group--with an alkali salt of 2,5-dimethylphenol of Formula (II) ##STR3## or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.

The invention relates to new compounds of the general formulae (I) and/or (II), ##STR1## wherein R.sup.1 is a C.sub.1-6 alkyl or an aralkyl group, and

Trimethylsilylcarbamates and a process for the preparation thereof

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Budapest, Hungary

Ferenc Szederkenyi