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Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Teva Gyógyszergyár Zártkörúen Múkó´dó´résvénytársaság

Ferenc Rantal

Vilmos Keri

Andrea Csorvasi

Irun R Cohen

Jeffrey Sterling

Meir Shinitzky

Yaacov Herzig

Raanan Margalit

Tivadar Tamas

Gyorgy Toth

Istvan Miskolczi

Janos Rako

Zoltan Czövek

Basic esters of fatty alcohols of the general formula: R1-O&#x2014;CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C-Calkyl or C-Calkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.

Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents

Provided is a method for obtaining a macrolide, especially tacrolimus, ascomycin, pimecrolimus, sirolimus, or everolimus, from biomatter.

Method for extracting a macrolide from biomatter

Provided is a method of purifying a macrolide, especially tacrolimus, that includes loading macrolide onto a bed of sorption resin and elting with a suitable eluent such as a combination of water and tetrahydrofuran.

Method of purifying macrolides

Growing community of inventors

Debrecen, Hungary

Ferenc Rantal