Biogal Gyogyszerarugyar Rt

Ferenc Radnai

Vilmos Keri

Janos Balint

Istvan Melczer

Gyorgy Deak

Gyongyi Strbka

Berta Mako

Erno Karacxony

Tibor Szanya

Csaba Hajdufi

Judit Dencs

Laszlo Hanak

Gyula Marton

Janos Kelemen

Edit Nagy

Anita Karczub

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

Process for the purification of cyclosporin A

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Debrecen, Hungary

Ferenc Radnai