Ab Kabi

Kabivitrum Ab

Ferenc Merenyi

Gunnar Hanshoff

Lennart E Karlsson

Pinchas Moses

Nils A Jonsson

Nils Ake Jonsson

Carl Magnus Svahn

Lars-Erik Westlund

Aake N Joensson

Barbro K Goransson-Dahlander

Novel antifibrinolytically active compounds of the formula ##STR1## and therapeutically acceptable salt thereof, wherein

Antifibrinolytically active derivatives of tranexamic acid

New compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R.sup.3 represents hydrogen, halogen, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, an amino group or a nitro group, A represents ##STR2## which is bonded to the benzene ring by its sulphur or nitrogen atom and in which R.sup.4 is hydrogen or an alkyl group containing 1 to 4 carbon atoms; together with salts thereof with physiologically acceptable acids and, when R.sup.4 is hydrogen, with physiologically acceptable bases are described. The compounds are of use in inhibiting thrombosis formation, in treating thrombosis and in fibronolytic therapy. Various methods of producing the new compounds are described involving the building up of the --A--CH.sub.2 --CH.sub.2 --S--CH.sub.2 CH.sub.2 NH.sub.2 side chain from aromatic precursors having an incomplete side chain or by introducing at least one of the R.sup.1, R.sup.2 or R.sup.3 substituents into a precursor lacking that substituent or from an amino-protected precursor.

Anti-thrombotic N-alkylthioakylamino benzenesulfonamides

The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with physiologically acceptable acids. In formula I R.sup.1 signifies hydrogen, halogen or alkoxy radicals having 1-3 carbon atoms, R.sup.2 and R.sup.3 signify alkyl radicals having 1-3 carbon atoms, which togetner with the carbon atom, to which they are connected, may form a ring, A either signifies a possibly lower alkyl substituted ethylene, trimethylene or tetramethylene group, in which case D is a group ##STR2## wherein R.sup.4 and R.sup.5 individually signify hydrogen or alkyl groups having 1-4 carbon atoms, or together with the nitrogen atom form a heterocyclic ring, which in addition to said nitrogen atom may contain an oxygen atom or possibly lower alkylated amino group, or A and B taken together signify a piperidino- or N-lower alkylpiperidino group, which is connected to an indene residue in 4-position, and the broken lines signify a double bond in either endo- or exo position.

Pharmacodynamically active indan derivatives

An analytical test, color change reagent preparation comprising peroxidase, an oxygen-oxidoreductase specific to a particular substance to be tested and a chromogen-reactive-indicator formula selected from (a) those having the general formula ##STR1## wherein X is the divalent carbonyloxy or sulfonyloxy group, W is hydrogen or another cation compatible with the aforesaid other ingredients of said reagent preparation, the subscript n is 0 or 1, and (i) when X is the carbonyloxy group, A is a divalent alkylene chain with from 2 to about 7 carbons, and (ii) when X is the sulfonyloxy group, n is 0 when A is the divalent alkylene chain of from 2 to about 7 carbons, and n is 1 when A is straight chain trimethylene or tetramethylene, and (b) the acid addition salts of said disubstituted benzidine derivative, compatible with the aforesaid ingredients of the chromogen-reactive-indicator, when X is the carbonyloxy group. The reagent preparations may be used in assaying organic substances such as sugars, uric acid, an amino acid and pyridoxaminophosphate.

Chromogen-reactive-indicator preparations containing A

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Taby, Sweden

Ferenc Merenyi