Debreceni Egyetem

Other

Bracco Imaging S.p.a.

Ferenc Krisztián Kálmán

Gyula Tircsó

Zoltán Garda

Imre Tóth

Richárd Botár

Tamás Fodor

Viktória Nagy

Alessandro Maiocchi

Simona Ghiani

Zsolt Baranyai

László Krusper

The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes. The other subject of the invention is the application of the above compounds. The compounds of general formula (I): wherein &#x2014;NRRgroup may refer to: a) &#x2014;NRRwith N atom in the ring means a ring of 4 to 7, that in certain cases may contain another heteroatom, and in specific cases the ring may be replaced with an aryl group (of 5 to 7 carbon atoms) substituted with &#x2014;COOH, &#x2014;OH, &#x2014;OCH, &#x2014;NO, &#x2014;NH, &#x2014;NCS, &#x2014;NHS-activated ester, aryl (of 5 to 7 carbon atoms), or nitro-, amino- or isothiocyanate group, or b) in the &#x2014;NRRgroup R means a H atom, alkyl, aryl, nitroaryl, aminoaryl or isothiocyanate-aryl group (of 1 to 6 carbon atoms) and Ris a H atom, alkyl (of 1 to 6 carbon atoms) or &#x2014;(CH)&#x2014;COOH group, whereas n=1 to 10 integer, or c) &#x2014;NRRgroup is one of the following groups: (formula II) whereas Ris a H atom, carboxyl- or alkyl-carbonyl group (of 1 to 4 carbon atoms); (formula III) and Ris a H atom or alkyl or aryl group (of 1 to 6 carbon atoms), and X means independently from one another H atom, &#x2014;CH, &#x2014;COOH, &#x2014;OH, &#x2014;OCH, alkoxy- (of 2 to 6 carbon atoms), &#x2014;NO, &#x2014;NH, &#x2014;NCS, &#x2014;NHS-activated ester, alkyl (of 2 to 12 carbon atoms) or aryl (of 5 to 7 carbon atoms) group, in certain cases the latter may be substituted with hydroxyl, hydroxyalkyl (of 1 to 6 carbon atoms), nitro, amino or isothiocyanate group. 

2,11-diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based MRI contrast agents and 52MN based PET contrast agents

A compound of the following general formula (I), and isomers, physiologically acceptable salts, and complexes thereof, for use as a contrast agent in diagnostic imaging: 

3,6,9, 15-tetraaza-bicyclo [9.3.1]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents

3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents

The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III), Co(II) and Ni(II) complexes and their application: where R|=&#x2014;OH or &#x2014;NRRamide functionality. 

6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI andMN based PET contrast agents

The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.

Ethylenediaminetetraacetic acid bis(amide) derivatives and their respective complexes with Mn(II) ion for use as MRI contrast agent

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Debrecen, Hungary

Ferenc Krisztián Kálmán