Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Biotie Therapies Corporation

Bioblocks Magyarorszag Gyogyszerkemiai Es Fejleszto Kft.

Lipidart Kutato Fejleszto Es Tanacsado Kft.

Ferenc Fulop

Gabor Bernath

Laszlo Szporny

Eva Palosi

Gyorgy Hajos

Elemer Ezer

Laszlo Denes

Jeno Kobor

Zsolt Szakonyi

Laszlo Lazar

Istvan Hermecz

Zoltan Meszaros

David Smith

Marjo Pihlavisto

Ferenc Miklos

Lorand Kiss

Auni Juhakoski

Marta Palko

Istvan Szatmari

Sandor Virag

Jozsef Knoll

Gabor Nagy

Peter Szentmiklosi

Egon Karpati

Bela Kiss

Erzsebet Lapis

Gábor Balogh

Zsolt Szombathelyi

Katalin Csomor

Judit Laszy

Aniko Gere

Adam Sarkadi

Sandor Szabo

Mihaly Bodo

Pal Sohar

Alajos Kalman

Gabor Motika

Zsolt Szentirmai

Pal Perjesi

Attila Sohajda

Judit Arva

Imre Huber

Jen Kobor

Josef Knoll

Laszlo Vigh

Sandor Bernath

Zsolt Torok

Akos Hunya

Ibolya Horvath

Botond Penke

The invention relates to pyridazinone and pyridone compounds having formula (I) or (I'), and pharmaceutically acceptable salts, hydrates, and solvates thereof wherein R/Rand X and Xare as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof.

Pyridazinone and pyridone compounds

The invention relates to pyridazinone and pyridone compounds having formula (I) or (I'), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R/Rand X and Xare as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof. 

Pyridazinone compounds

The invention relates to chiral cyclic &#x3b2;-amino acids of Formula (I) and their salts formed with pharmaceutically acceptable acids or bases, wherein the main meanings of the substituents are as follows: R stands for CAlk; X stands for &#x2014;COOH, &#x2014;CONH, &#x2014;CONH(CAlk), &#x2014;CON(CAlk), &#x2014;COO(CAlk), &#x2014;COPhe-O&#x2014;(CAlk) or &#x2014;CHOH; Y stands for &#x2014;NH, &#x2014;NHBoc, &#x2014;NHFmoc, &#x2014;NH(CAlk), &#x2014;N(CAlk), &#x2014;NHCHPh, or Ar&#x2014;NH&#x2014;C(&#x2550;X)&#x2014;N(R)&#x2014; wherein Ar stands for a phenyl group substituted by Calkoxy or halogen, Xstands for O or S, and Rstands for hydrogen or benzyl; and X+Y stands for &#x2014;CONH&#x2014; vagy &#x2014;CON(Boc)-; with the proviso that when X stands for &#x2014;COOH, then Y may be only different from &#x2014;NH. The invention also relates to pharmaceutical compositions having multidrug-resistance reversing effect that contain one or more compound(s) of Formula (I) or a salt thereof and inert pharmaceutical carriers and/or auxiliary agents. The invention also relates to carboxylic acids of Formula (XX) and their salts.

Chiral cyclic &#x3b2;-amino acids and their derivatives, pharmaceutical compositions containing them and the use of such compounds

Substituted oxazinoisoquinoline derivatives, pharmaceutical compositions

The invention relates to new N-substituted bis(hydroxymethyl)-methyl-isoquinoline derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

N-substituted isoquinoline derivatives and pharmaceutical compositions

The invention relates to new 1-[bis(hydroxymethyl)-methyl]-3,4-dihydro- or -1,2,3,4-tetrahydroisoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Isoquinoline derivatives, and pharmaceutical compositions containing them

The invention relates to new bis(substituted methyl)-methyl-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

Bis(substituted methyl)-methyl-isoquinoline derivatives and

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms,

2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions

Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereof

Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment

Pharmaceutical intermediates, morphine potentiators and other compounds have the formula ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy, nitro, amino, carboxy or a carboxylic acid derivate radical, R.sup.1 is hydrogen or a C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen, R.sup.4 is hydrogen or C.sub.1-4 alkyl, R.sup.5 is hydrogen R.sup.6 is hydrogen or R.sup.3 and R.sup.4 and/or R.sup.5 and R.sup.6 form a chemical bond, X is oxygen or imino, m is 1, 2, 3 or 4, n is 0, 1, 2 or 3, and if n is 1, then the dotted lines can stand for bonds, with the proviso that if m=1 and n=1 and if in the 2,3-, 6,7-, 8,9- and 1,10-positions double bonds are present, and R.sup.1 and R.sup.2 are hydrogen, then R is other than 9-hydroxy or 9-methyl; if m=2 and n=1 and R.sup.2 is hydrogen, then at least one of R and R.sup.1 is other than hydrogen; and if m=2 and n=2 and R.sup.2 is hydrogen and the molecule is a 2,3,4,6,7,8,9,10-octahydro derivative, then at least one of R and R.sup.1 is other than hydrogen or an acid-addition or quaternary salt thereof.

2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines

Compounds of the formula: ##STR1## or pharmaceutically acceptable acid addition or quaternary ammonium salts thereof wherein

Pyrido[1,2-a]pyrimidine derivatives

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Szeged, Hungary

Ferenc Fulop