Thalesnano Zrt.

Szegedi Tudomanyegyetem

Cominnex Zrt

Druggability Technologies IP Holdco (jersey) Ltd.

Darholding Vagyonkezelo Korlatolt Felelossegu Tarsasag

Thalesnano Nanotechnológiai Zrt.

Echemicles Zrt.

Darholding Vagyonkezelö Kft.

Nanoform Cardiovascular Therapeutics Limited

Ferenc Darvas

Dániel Szalay

Lajos Gödörházy

Ferenc Boncz

Zsolt Ötvös

Tamás Karancsi

Balázs Endrödi

László Ürge

Csaba Janáky

Egon Kecsenovity

Antal Danyi

Richard Jones

Viktor Török

Daniel Szalay

Lajos Godorhazy

Tamas Karancsi

Genovéva Filipcsei

László Csaba Lengyel

Norbert Varga

Teréz Vágó

Gábor Heltovics

Krisztián Niesz

Angelika Samu

Atilla Wootsch

Maxime Groualle

Attila Wootsch

An electrolyzer cell, electrolyzer setup, and related methods are provided for converting gaseous carbon dioxide to gas-phase products at elevated pressures with high conversion rates via electrolysis performed by the electrolyzer cell (″). The electrolyzer cell (″) is a multi-stack COelectrolyzer cell having individual stacks () that each include bipolar plate assemblies that have unique gas and fluid flow architecture formed therein.

Modular electrolyzer stack and process to convert carbon dioxide to gaseous products at elevated pressure and with high conversion rate

The present invention relates to the field of generating gaseous hydrogen at high pressures and with high purity via electrolysis of water by means of an electrolyzer unit () with a novel structure.

Modular electrolyzer unit to generate gaseous hydrogen at high pressure and with high purity

A mesofluidic reactor performs a chemical reaction of a starting material. A liquid phase starting material is introduced into a spraying head equipped with an ultrasound generating piezoelectric crystal unit. An inert/reagent gas feeds into the spraying head, connected to a reactor tube arranged within a thermally insulated multi-zone heating unit. For solid phase, an inert/reagent gas is introduced into a solids container connected to a spraying head equipped with an ultrasound generating piezoelectric crystal unit. The spraying head connects to a reactor tube arranged within a thermally insulated multi-zone heating unit. In either case, a reactor tube outlet connects to a cooled product trap to collect conversed substances. The spraying head generates a particle size distribution with nano and micro sized particles for the liquid phase and nano, micro or larger particles for the solid phase. The inert/reagent gas is preheated over the piezoelectric crystal unit's surface.

Mesofluidic reactor with pulsing ultrasound frequency

The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

Nanostructured aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them

A continuous flow system for the synthesis of nanoparticles includes a feeding unit connected to the first reactor a flow path, at least one first reactor unit possessing a heatable reactor-zone, a second reactor unit which follows the first reactor in the same cascade; a mixing unit and a second feeding unit between the reactor units, and feeding pumps connected to a raw material source and/or a control unit which is capable of controlling at least one pressure controller and/or controlling the temperature of at least one heatable reactor-zone; each heatable reactor-zone is followed by a cooling unit in the cascade. In addition, a process for the synthesis of nanoparticles, preferably metal-containing nanoparticles, and nanoparticles of biologically active organic molecules wherein the process is accomplished using the system.

Instrument and process for nanoparticles production in continuous flow mode

The invention relates to a porous electrode used in an electrochemical cell, containing a carrier and/or catalytic agent, which is characterized by that it consists of two or more layers with different average pore sizes, out of which layers the contact layer with the smallest average pore size is in contact with the membrane, and one or more supporting layers with a greater average pore size are linked to the other side of this contact layer. Furthermore, the invention relates to a procedure for the manufacturing of such electrodes and to electrochemical cells containing such electrodes.

Electrode for electrochemical cell operating with high differential pressure difference, procedure for the manufacturing of such electrode and electrochemical cell for the use of such electrode

A process for hydrogenating a sample in a pressure range below supercritical pressure values includes supplying at least a solvent of the sample to be hydrogenated by a feed pump with a constant volume rate into a flow path to create a base solution; adding the sample being dissolved into the flow path; feeding hydrogen into the flow path through a valve configured to transmit hydrogen only into a single direction; leading the dissolved sample in the presence of a catalyst through a hydrogenation reactor, where the reactor is inserted into a section of the flow path located after the hydrogen feeding position; maintaining the pressure of the reaction in a given pressure range by element of a pressure-adjusting unit, and collecting a hydrogenate formed within the hydrogenation reactor in a product receptacle connected to the end of the flow path.

Laboratory scale continuous flow hydrogenation process

The present invention relates to a method of forming a sealed channel on the surface of a sheet made of a material with a particular extent of plasticity, the sheet forming a reactor block for a microfluidic reactor.

Method of forming a sealed channel of a microfluidic reactor and a microfluidic reactor comprising such channel

A laboratory scale continuous flow hydrogenation apparatus () includes a reservoir (), a feed pump (), a mixing element () with two inlets and an outlet, a hydrogenation reactor () and a pressure-adjusting unit (), all connected into a flow path. A hydrogen source () and a one-way valve () are arranged between the hydrogen source () and the second inlet of the mixing element (). The feed pump () can provide a constant volume rate. The reservoir () contains at least a solvent base solution of the sample to be hydrogenated. The hydrogenation reactor () connects into the flow path by detachable connections and is formed as a replaceable cartridge containing a packing which increases the flow resistance and facilitates mixing. The pressure-adjusting unit () connects into the flow path after the hydrogenation reactor () and is provided with a regulation controlled electrically.

Flow-type laboratory hydrogenation apparatus and laboratory hydrogenation process using the apparatus

Growing community of inventors

Budapest, Hungary

Ferenc Darvas