Academisch Medisch Centrum Bij De Universiteit Van Amsterdam

Cancer Research Technology Limited

Aimm Therapeutics B.v.

Ferenc A Scheeren

Hergen Spits

Tim Beaumont

Sean A Diehl

Marianne Naspetti

Bianca Blom

Hergen The Netherlands Cancer Inst Spits

M The Netherlands Cancer Inst Naspetti

The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.

Means and methods for influencing the stability of antibody producing cells

The invention provides methods for maintaining cell lines from primary cells, i.e., non-transformed cells, using expression of the signal transducer of activation and transcription (STAT). The methods are particularly suitable for maintenance of B-cells.

Materials and methods relating to the production and maintenance of cell lines

The invention provides methods for maintaining cell lines from primary cells, i.e. non-transformed cells, using expression of the signal transducer of activation and transcription (STAT). The methods are particularly suitable for the maintenance of B-cells.

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Amsterdam, Netherlands

Ferenc A Scheeren