US Government As Represented by the Secretary of the Army

University of Massachusetts

Other

Ferdinando F Bruno

Lynne Ann Samuelson

Jayant Kumar

Ramaswamy Nagarajan

Joseph A Akkara

Ashok L Cholli

Vijayendra Kumar

Virinder Singh Parmar

Susan Tripathy, Legal Representative

Wei Liu

Michael S Sennett

Nicole Favreau

David L Kaplan

Jonathan S Dordick

Sukant K Tripathy

Bon-Cheol Ku

David Ziegler

Nicole F Farhadi

Javant Kumar

Manuele Bernabei

Sucharita Roy

Soo-Hyoung Lee

Ltc Andrea Chiappa

Ashish Dhawan

Kenneth A Marx

Christopher P Drew

Braja K Mandal

Susan J Braunhut

Donna McIntosh

Subhalakshmi Nagarajan

Kenneth Racicot

Klaudia Foley

The disclosed subject matter relates to a method of treating of asbestos or asbestos-containing material, comprising applying to the asbestos or asbestos-containing material a composition including a treatment compound comprising at least one of hexafluoro titanium di-ammonium, potassium hexafluoro zirconate. ammonium hexafluoro phosphate. ammonium hexafluoro stannate, ammonium hexafluoro germanate, ammonium tetrafluoro borate or ammonium heptafluoro tantalite; and a fluorine scavenger compound.

Abatement of asbestos using fluorinated metal compounds

Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant.

Separation of enzymatically synthesized polyepicatechin via high performance liquid chromatography

Disclosed is a separated fraction of a reaction product of an enzymatically catalyzed polymerization of a flavonoid. The separated fraction is highly resistant to oxidation and is useful in numerous applications such as an antioxidant in food products and medical applications.

Liquid chromatographic fraction of enzymatically polymerized flavonoid as an antioxidant

A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.

Synthesis of oligo/poly(catechins) and methods of use

The present invention provides a method of producing polyhydroxytyrosol comprising the step of reacting hydroxytyrosol monomers or derivative thereof in a mixed solution comprising an enzyme, hydrogen peroxide, and an aqueous solvent.

Polymerization of hydroxytyrosol mediated by horseradish peroxidases

The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at least one flavonoid in the presence of an enzyme and hydrogen peroxide in an aqueous solution.

Copolymerization of hydroxytyrosol with flavonoids mediated by horseradish peroxidases

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: The invention also includes methods of using and preparing these polymers.

Polymeric antioxidants

Nanometer scale structures, and methods of making the same are disclosed.

Nanometer scale structures

The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is &#x2014;H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one &#x2014;H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.

A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R, R, R, Rand Rare independently &#x2014;H, &#x2014;OH, &#x2014;NH, &#x2014;SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R, R, R, Ror R, in conjunction with an adjacent R, R, R, Ror R, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R, R, R, Ror Ris a tert-butyl group-ethenyl--carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R, R, R, Ror Ris a hydroxyl group, and at least one of R, R, R, Rand Ris &#x2014;H; with a protecting group, wherein thereby obtaining one or more protected hydroxyl groups; and b) polymerizing the substituted or unsubstituted phenol, thereby obtaining the phenolic polymer.

An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.

Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein:

Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.

Growing community of inventors

Andover, MA, United States of America

Ferdinando F Bruno