Isa Pharmaceuticals B.v.

Stichting Voor De Technische Wetenschappen

Academisch Ziekenhuis Leiden (h.o.d.n. Lumc)

Ferdinand Antonius Ossendorp

Selina Khan

Cornelis Johannes Maria Melief

Gijsbert Arie Van Der Marel

Dmitri Viktorovitsj Filippov

Jan Wouter Drijfhout

Cornelis Joseph Maria Melief

The invention is directed to a compound according to the formula [1] wherein Rand Rare branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or O and R is &#x2014;OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.

Adjuvant compound

The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL (residues 383-390 of SEQ ID NO: 3) for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.

Peptides, conjugates and method for increasing immunogenicity of a vaccine

The invention is directed to a compound according to the formula [1] wherein Rand Rare branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is &#x2014;OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.

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Amstelveen, Netherlands

Ferdinand Antonius Ossendorp