Salford Ultrafine Chemicals & Research Ltd.

Ufc Corporation

Feodor Scheinmann

Neil Edward Carter

Richard Talbot Brown

Stephen Patrick Mayalarp

Andrew Valentine Stachulski

Nicholas John Turner

Keith William Lumbard

Jane Louise Law

Jonathan David Hull

Simon Joel

John Ferguson

Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates

Process for the preparation of optically active methadones in high

##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.

Process for making morphine-6-glucuronide or substituted

A method of making morphine-6-glucuronide comprising the selective enzymatic cleavage of the 3-glucuronide moiety in morphine-3, 6-glucuronide or substituted morphine-6-glucuronide using at least one .beta.-glucuronide.

Enzymatic process for making morphine-6-glucuronide or substituted

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Cheshire, United Kingdom

Feodor Scheinmann