Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Fengying Guo

Xin Xu

Zhen Zhang

Yunfei Li

Jian Ge

Yijin Wang

Liming Zhang

Qingyun Jiang

Lei Liu

Qiang Liu

Jia Chen

Hao Yu

Jing Su

Dongsheng Li

Xiaobo Zhou

Kang Sun

Xiaoer Xia

Xiaojuan Zhang

Linli Zhang

Yuyun Zhang

Qimei Wu

Chengxu Zang

Jinqian Song

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Disclosed are a class of &#x3bc;-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The &#x3bc;-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

&#x3bc;-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

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Shanghai, China

Fengying Guo