Jiangnan University

Fengwei Tian

Hao Zhang

Jianxin Zhao

Gang Wang

Qixiao Zhai

Yuanda Song

Yongquan Chen

Daming Fan

Wenwei Lu

Zhennan Gu

Qiuxiang Zhang

Xiaoming Liu

Haiqin Chen

Huizi Tan

Meiyi Zhang

Leilei Yu

Wei Chen

Shumao Cui

Shunhe Wang

Min Guo

Haiqun Chen

Feifei Chi

Wenli Huang

The disclosure discloses a strain ofcapable of preventing and/or treatinginfection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain ofCCFM1118. TheCCFM1118 can inhibit, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of theCCFM1118 oncan reach 13.14 mm; and (2) theCCFM1118 can significantly reduce the adhesion ofto AGS cells. Therefore, theCCFM1118 has great application prospects in inhibiting(not for the purposes of disease diagnosis and treatment) and preparinginhibitors.

Strain ofcapable of preventing and/or treatinginfection

The disclosure discloses a strain ofand application thereof in inhibiting, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain ofCCFM1119. TheCCFM1119 can prevent and/or treatinfection, specifically embodied in that: (1) theCCFM1119 can significantly relieve the gastrointestinal symptoms of patients withinfection; (2) theCCFM1119 can significantly reduce the amount of colonization ofin patients withinfection; and (3) theCCFM1119 can significantly increase the clearance rate ofin patients withinfection. Therefore,CCFM1119 has great application prospects in the preparation of products (such as food or medicine) for preventing and/or treatinginfection.

Strain ofand application thereof in inhibiting

The disclosure disclosesfor relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. TheCCFM1020 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of hosts infected with endotoxin, up-regulate the number of Foxp3regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of theCCFM1020 for relieving endotoxin infection has broad application prospects.

for relieving endotoxin infection and application thereof

The disclosure disclosesfor relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. TheCCFM1021 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of mice infected with endotoxin, up-regulate the number of Foxp3regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of theCCFM1021 for relieving endotoxin infection has broad application prospects.

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An anti-oxidativeCCFM1107 can relieve chronic alcoholic liver injury, andCCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containingCCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

The invention provides a novel strain of cadmium-removingbacterium, CCFM8610, which has a good tolerance to acidic environments.CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion.CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.

TheCCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.

Protective effects and application of a lactobacillus plantarum on the alleviation of lead toxicity

The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially &#x3c9;3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.

Fatty acid desaturase used in the biosynthesis of long chain omega-3 polyunsaturated fatty acids

The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially delta-9 desaturases (FADS9-I). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.

Delta-9 desaturase used in the biosynthesis of polyunsaturated fatty acids

The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially omega-3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.

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Wuxi, China

Fengwei Tian