Senomyx, Inc.

Firmenich Incorporated

Feng Zhang

Xiaodong Li

Catherine Tachdjian

Guy Servant

Qing Chen

Donald Karanewsky

Vincent Darmohusodo

Hong Zhang

Xiao-Qing Tang

Albert Zlotnik

Richard Masten Fine

Boris Klebansky

Marketa Rinnova

Timothy Davis

Victor Selchau

Melissa Sue Wong

Xinshan Kang

Haitian Liu

Mark Zoller

Xiao Qing Tang

Sara Werner

Qing Li

Hong Xu

Joseph R Fotsing

Sara L Adamski-Werner

Jeffrey Robert Hammaker

Goran Petrovic

Rachel D A Kimmich

Jeffrey Yamamoto

Donald S Karanewsky

Rachel DA Kimmich

Sara Adamski-Werner

The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

Sweet flavor modifier

The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Modulation of chemosensory receptors and ligands associated therewith

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.

Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines

This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.

Assays using chimeric T1R polypeptides for identifying putative taste modulatory compounds

The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors: These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

Chimeric human sweet-umami and umami-sweet taste receptors

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San Diego, CA, United States of America

Feng Zhang