Bracco International Bv

Bracco Suisse Sa

Bracco Research Sa

Dyax Corporation

Koninklijke Philips Corporation N.V.

Feng Yan

Michel Schneider

Philippe Bussat

Jean Brochot

Jerome Puginier

Marie-Bernadette Barrau

Kondareddiar Ramalingam

Adrian D Nunn

Karen E Linder

Edmund R Marinelli

Palaniappa Nanjappan

Radhakrishna K Pillai

Mathew A Von Wronski

Daniel Bichon

Eva Hybl

Rolf E Swenson

Bo Song

Sibylle Pochon

Ajay Shrivastava

Christophe Arbogast

Hong Fan

Aaron Sato

Daniel T Dransfield

Christian Guillot

Anne Lassus

Sudha Khurana

Pascal Grenier

Nadine Garcel

J&eacute;r&ocirc;me Puginier

Pascal Grenier, Deceased

Robert Charles Ladner

Daniel J Sexton

Michael F Tweedle

Natarajan Raju

Peter Frinking

Marcel Arditi

Sharon Michele Walker

Thierry Bettinger

Stéphane Gorgerat

Laurent Jakob

Christophe Golay

Jeffry E Powers

William Tao Shi

Ralf Seip

Herve Tournier

Nicolas Rognin

Hong (Helen) Fan

Eric Allemann

Emmanuel Jean-Marie Gaud

Christian Mathieu

Jean-Marc Paul Robert Hyvelin

Yannick Bohren

Stephane Gorgerat

Sophie Mehier-Humbert

Mathieu Hauwel

Anne Senente

Sybille Pochon

Nadine Garcel, Legal Representative

Nadine Gercel, Legal Representative

Maria-Bernadette Barrau

Francois Tranquart

Jèróme Puginier

Ebeline Bihel

Agn&eacute;s Hiver

Jeffry Earl Powers

Jean-Marc Paul Hyvelin

François Tranquart

Aaron K Sato

A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.

Freeze-dried product and gas-filled microvesicles suspension

Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.

Devices and methods for the ultrasound treatment of ischemic stroke

A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.

Freeze-dried formulation for gas-filled microvesicles

Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component&#x2014;MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

Gas-filled microvesicle assembly for contrast imaging

Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.

Gas-filled microvesicles with polymer-modified lipids

The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K&#x3c;1 &#x3bc;M), and dimer and multimeric constructs comprising these polypeptides.

KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K&#x3c;1 &#x3bc;M), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.

Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.

Composition comprising gas-filled microcapsules for ultrasound mediated delivery

Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.

Ultrasound contrast agents and process for the preparation thereof

A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number.

Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis

Pharmaceutical kit comprising (i) a targeting construct which comprises a targeting ligand and an anti-polymer antibody and (ii) a polymer-containing liposome or gas-filled microvesicle capable of binding or associating to said construct. Also disclosed are methods of preparing and of administering said assembly, as well as an assembly comprising said targeting construct and said liposome or gas-filled microvesicle.

Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same

The invention provides compositions and methods for therapeutic and diagnostic applications.

Multivalent constructs for therapeutic and diagnostic applications

Growing community of inventors

Grand-Lancy, Switzerland

Feng Yan