University of Texas System

Feng Wang-Johanning

Simon Olivares

Hiroki Torikai

Ling Zhang

Helen Huls

Lenka Hurton

Janani Krishnamurthy

Laurence J N Cooper

Laurence Jn Cooper

Horoki Torikai

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

Human application of engineered chimeric antigen receptor (CAR) T-cells

Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-Kcancers are provided. One example of a method may involve a method for preventing or inhibiting cancer cell proliferation by administering to a subject a cancer cell proliferation blocking or reducing amount of a HERV-K env protein binding antibody.

HERV-K antigens, antibodies, and methods

Growing community of inventors

Bastrop, TX, United States of America

Feng Wang-Johanning