California Institute of Technology

The University of Chicago

Talis Biomedical Corporation

Slipchip Corporation

Feng Shen

Rustem F Ismagilov

Jason E Kreutz

Wenbin Du

Bing Sun

Liang Li

Delai Chen

Hedia Maamar

David A Selck

Chris Da Costa

Kevin Paul Flood Nichols

Espir Kahatt

Erik B Jue

Matthew S Curtis

Philip Homewood

Nathan G Schoepp

Eugenia Khorosheva

Stefano Begolo

Travis S Schlappi

Yu-Hsiang Hsu

Mikhail Karymov

Philip James Homewood

Stephanie McCalla

Joe Baker

Jason Eugene Kreutz

Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

Microfluidic measurements of the response of an organism to a drug

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

Slip chip device and methods

Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.

Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes

The present invention relates to fluidic systems for controlling one or more fluids or reagents. These systems can be used in combination with one or more devices for assaying, processing, or storing samples. In particular, the systems and related methods can allow for controlled pressure and actuation of fluids.

Sample preparation module with stepwise pressurization mechanism

The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.

System and method for movement and timing control

Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.

Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.

Fluidic devices and systems for sample preparation or autonomous analysis

The present invention relates to fluidic devices for compartmentalizing samples. In particular, the devices and related systems and methods allow for compartmentalization by using one or more first chambers connect by a first channel (e.g., where the cross-sectional dimension of the first channel is less than the cross-sectional dimension of at least one first chamber).

Slip-induced compartmentalization

Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes

Growing community of inventors

Chicago, IL, United States of America

Feng Shen