Medical and Pharmaceutical Industry Technology and Development Center

Pharmaceutical Industry Technology and Development Center

National Science Council

National Science Council of Republic of China

Oneness Biotech Co.

Feng-Nien Ko

Cheng-Ko Liu

Mo-Chi Cheng

Yu-Feng Han

Che-Ming Teng

Pin-Fun Chen

Chien-Jen Shih

Tian-Shung Wu

Jen-Wei Chen

Je-Yie Lin

Pey-Chyi Wu

Sheng-Chu Kuo

Yuan-Ling Ku

Chao-Chi Yei

Fen Chen

Shwu-Jen Wu

Yu-Hsuan Lin

Cherng-Chyi Tzeng

Ing-Jun Chen

Ji-Wang Chern

Yeh-Long Chen

Chun-Nan Lin

Tur-Fu Huang

Shorong-Shii Liou

Ying-Yu Kuo

Yueh-Chu Chen

Ih-Sheng Chen

Hsiao-Chu Huang

Shwu-Jen Liou

Wen-Ling Yang

Chun-Hung Kuo

Yi-Chen Lin

Shih-Tsun Liang

Liang-Hua Chen

Wei-Ja Wang

Pin-Fen Chen

Mai-Yu Lee

The invention provides an extract of(Lour.) Spreng enriching anti-arthritis activity, which is obtained by eluting the crude extract of(Lour.) Spreng using 50%&#x2dc;95% alcoholic solution or solvents such as hexane and/or ethyl acetate. Also provided is a method for treating arthritis comprising such extract.

Method for preparingfraction having anti-arthritis activity

A new use of a potent product extracted from rhizomes ofin treating a disease associated withsuch as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.

[object Object]

An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of thePoir extract as an active component. The effectivePoir extract is prepared by extracting the root-bark of thePoir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.

Antitussive composition and method for making the same

An extract prepared from the root barks ofPoir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent: 

The present invention discloses a new use of a potent product extracted from rhizomes ofin treating a disease associated withsuch as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.

An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.

Antitussive agent and method for making the same

A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R' and R&#x2033; independently are H or R, provided that R, R&#x2032; and R&#x2033; are not all H, wherein Ris wherein Ris hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, Ris H.

Polygalatenosides and use thereof as an antidepressant agent

A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.

Anti-depression pharmaceutical composition containing Polygala extract

The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.

Anti-ulcer pharmaceutical composition and the preparation thereof

The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, includingor the extract thereof, and a method for preparingextract, said method including extractingwith water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.

A method of treating a patient suffering a disease associated withorby applying topically an anti-fungal pharmaceutical composition which is prepared from, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.

Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale

A method of treating psychosis in a patient which comprises administering a pharmaceutical composition useful in treating psychosis containing a therapeutically effective amount of 1-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one as an active ingredient.

Method of treating psychosis in a patient

A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.

Anti-depression pharmaceutical composition containing polygala extract

Growing community of inventors

Taipei, Taiwan

Feng-Nien Ko