Alcon, Inc.

Georgia-pacific Chemicals LLC

Novartis Ag

Segetis, Inc.

Gfbiochemicals Limited

Gfbiochemicals IP Assets B.v.

Feng Jing

Frank Chang

Steve Yun Zhang

Daqing Wu

Ying Zheng

Jinyu Huang

Xinming Qian

Junhao Ge

Richard Charles Breitkopf

Bobby Lee Williamson

Augustine Twum Kumi

Weihong Lang

Zach Munoz

Matthew D Nelson

Cornel Hagiopol

Troy Vernon Holland

Brian Lee Swift

Adam K Sniady

Ramji Srinivasan

John Dallas Pruitt

Chung-Yuan Chiang

Marc D Scholten

Brian Daniel Mullen

Ryan DeSousa

Jing Cheng

Vivek Badarinarayana

Houliang Tang

Steven A Donen

Sergey A Selifonov

Dorie Janine Yontz

Cora Leibig

Yuan Chang

John D Cothran

Michelle Plavnik

Friederike Stollmaier

Marc Davis Scholten

Steven Donen

Friederike Theresia Stollmaier

Jang-Shing Chiou

Irving D Sand

Ryan Desousa

Cora M Leibig

Adam Edward Goetz

Marc David Rodwogin

Stephen Raymond Perreault

Andrew J Louwagie

Bobby L Williamson

Ya-Wen Chang

Jack W Trieu

Fei Cheng

Tara J Mullen

Sergey Selifonov

Brian L Swift

A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising repeating units of a free-radical photoinitiator; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; actinically curing both the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

Method for making embedded hydrogel contact lenses

The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C-Calkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

Method for producing wettable silicone hydrogel contact lenses

The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C-Corganic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof

Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).

Method for making photochromic contact lenses

The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.

Contact lens packaging solutions

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Silicone hydrogel contact lenses

The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

Poly(meth)acrylamide-based copolymers with carboxyl-terminated pendant chains

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Snellville, GA, United States of America

Feng Jing