National Health Research Institutes

National Taiwan University

Other

Purzer Pharmaceutical Co., Ltd.

National Taipei University of Technology

Body Organ Biomedical Corp.

Purzer Pharmaceuticals Co. Ltd.

Fawell Medicine Co.

Feng-Huei Lin

Chun-Jen Liao

Chun-Pin Lin

Chia-Ming Chang

Hsu-Wei Fang

Ko-Hua Chen

Chung-King Hsu

Wen-Yu Su

Tzu-Piao Tang

Hsuan-Yu Chen

Yu-Chun Chen

Tzu-Wei Wang

Jui-Sheng Sun

Horng-Ji Lai

Gin-Shin Chen

Chien-Cheng Lin

Shang-Ming Lin

Ching-Yun Chen

Ya-Jung Hung

Tzu-Chien Chen

Rui-Chian Tang

Jiun-Jung Chen

Li-Chen Chiu

Yen-Hsien Lee

Hwa-Chang Liu

Chunching Li

Shing-Mou Lee

Chun-Che Yen

Cherng-Jyh Ke

Hsiang-Yin Lu

Pei-Jen Lou

Chun-Hsu Yao

Tzong-Fu Kuo

Ching-Li Tseng

Shian-chiuan Tzeng

Kuo-hsun Tseng

Chang-Chin Wu

Min-Huei Lin

Kai-Chiang Yang

Shu-wei Huang

The present invention discloses an therapeutic ultrasonic device consisting of at least one arc ultrasonic transducer that can be assembled. The arc ultrasonic transducer comprises a protruding part, a concave part and a plurality of piezoelectric vibrating parts. The protruding part and the concave part are disposed at two ends of the arc ultrasonic transducer respectively, and the piezoelectric vibrating parts are disposed at the inner arc face of the arc ultrasonic transducer. Various numbers of arc ultrasonic transducers can be used in assembled structure or non-assembled structure according to different body size and focal zones of various target tissue. Thus the therapeutic ultrasonic device of the present invention is widely used in treatment of various indications.

Therapeutic ultrasonic device and the use thereof

A pH-responsive hydrogel, which is synthesized by using mixed pectin and sucralfate treated with a small amount of acid to form a pH-responsive hydrogel. The pH-responsive hydrogel can form a temporary coating on the surface of the gastrointestinal tract to reduce excessive nutrient absorption, and exhibits excellent barrier properties and mucosal adhesion effects, which are useful for reducing blood sugar rise and weight gain, the liver fat accumulation, body fat accumulation and blood low-density lipoprotein that have a significant effect. In addition, the technical principles disclosed in the pH-responsive hydrogel should be applied to other polymer materials to manufacture different pH-responsive hydrogels.

PH-responsive hydrogel and manufacturing method thereof

The present invention discloses a desensitizing toothpaste. Based on the total weight of the desensitizing toothpaste, the desensitizing toothpaste includes: from 5% to 40% by weight of DP-bioglass; from 1% to 5% by weight of thickening agents; from 25% to 35% by weight of humectant; and from 1% to 5% by weight of surfactant, wherein the DP-bioglass includes: 8.4% of NaO, 40.6% of CaO, 39% of SiO, and 12% of PObased on the total weight of the DP-bioglass. With the implementation of the present invention, the indication of dentin hypersensitivity can be greatly relieved.

Desensitizing toothpaste

The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor.

Kit and method for promoting mesenchymal stem cell differentiation

An artificial tears solution combination is composed mainly of an anti-inflammation and anti-oxidation material, a liquid viscosity-enhancing agent, and an artificial tears solution. The artificial tears solution combination is capable keeping moisture, and meanwhile having anti-inflammation and anti-oxidation capabilities. As such, it can prolong the liquid retention on ocular surfaces, to effective reduce the repeated dosing, and shorten the schedule for the dry eye syndrome.

Artificial tears solution combination

Ophthalmic irrigating solutions are disclosed. The ophthalmic irrigating solution comprises: a) &#x3b3;-polyglutamic acid (&#x3b3;-PGA) and/or salt thereof in an amount effective to increase the viscosity of the irrigating solution, and b) an ophthalmically acceptable aqueous vehicle for the &#x3b3;-PGA and/or salt thereof. Also disclosed is a method of irrigating ocular tissues of a patient, in which the method comprises introducing to the ocular tissues of the patient an ophthalmic irrigating solution comprising &#x3b3;-PGA) and/or salt thereof in an amount sufficient to irrigate the ocular tissues of the patient.

Gamma-polyglutamic acid-based intraocular irrigation solutions

A corneal cover or corneal implant to be placed within or onto the surface of the cornea is made of bony fish scales and a contact lens is made of bony fish scales.

Corneal cover or corneal implant and contact lens and method thereof

A non-alcohol mouthwash composition without chemical antibacterial medicament is disclosed. The non-alcohol mouthwash composition includes from 0.03% to 1.5% of &#x3b3;-polyglutamic acid (&#x3b3;-PGA) and from 0.5% to 4% of surfactant, all percentages based on the total weight of the mouthwash composition. The non-alcohol mouthwash composition preferably includes from 0.4% to 1.5% by weight, or more preferably from 0.8% to 1.3% by weight, of &#x3b3;-PGA. Containing no chemical antibacterial medicament, the non-alcohol mouthwash composition can effectively inhibit bacterial growth in the oral cavity without irritating the oral mucosa.

Non-alcohol mouthwash composition without chemical antibacterial medicament

An implant containing a collagen matrix embedded with chondrocyte-like cells, its use in repairing a chondral defect, and a method of preparing the implant.

Surgical grafts for repairing chondral defects

A composition comprising a polymer that comprises oxidated hyaluronic acid cross-linked by a dihydrazide is disclosed. The polymer is a hydrogel exhibiting the following properties: a) transparent and colorless; and b) transforming from a liquid state into a gel-matrix at 37&#xb0; C. These characteristics make it useful as a vitreous humor substitute.

Cross-linked oxidated hyaluronic acid for use as a vitreous substitute

The present invention is related to an immuno-PCR method for detecting nasopharyngeal carcinoma (NPC) and kit thereof, especially related to an immuno-PCR method for detecting markers of early stage NPC and kit thereof. The present invention includes providing a substrate whereon protein markers immobilized; applying a patient's specimen to the substrate; adding a solution which has biotinylated anti-human IgA secondary antibody and incubating the solution; adding a solution with a linker and biotinylated target DNA; proceeding a polymerase chain reaction; and finally, detecting the target DNA fragments via electrophoresis.

Immuno-PCR method for detecting nasopharyngeal carcinoma markers and kit thereof

A biphasic cement of &agr;-TCP/HAP is primarily composed of 30-60 wt % &agr;-tricalcium phosphate (Ca (PO ) , &agr;-TCP) and 40-70 wt % of hydroxyapatite (Ca (PO ) (OH) , HAP). The biphasic cement of &agr;-TCP/HAP of the present invention is superior since it can set rapidly while soaking in a water solution. The present invention also provides a process for preparing the biphasic cement of &agr;-TCP/HAP, in which the composition of the biphasic cement of &agr;-TCP/HAP can be controlled.

&agr;-TCP/HAP biphasic cement and its preparing process

A bone substitute comprises gelatin powder, water, tricalcium phosphate (TCP) powder, and glutaraldehyde. The bone substitute in the present invention, using tricalcium phosphate powder as the major implant ingredient, gelatin powder as glue, and glutaraldehyde as cross-linking agent, can reduce the degradation rate of the bone substitute in the biological body. The present invention also includes the manufacturing procedure of the bone substitute.

Bone substitute composition and process of preparation thereof

A process for preparing porous bioceramic materials includes the following steps: (a) using the cancellous bone of animals, (b) removing organic substances in the cancellous bone by thermal processing to obtain de-organic cancellous bone, (c) soaking the de-organic cancellous bone in a solution of phosphate salts, and (d) obtaining porous bioceramic materials by sintering up to 900.degree. C. or higher after dehydration. The porous bioceramic materials of the present invention are suitable for use as filling materials for bone defect.

Process for preparing porous bioceramic materials

Growing community of inventors

Taipei, Taiwan

Feng-Huei Lin