Tunghai University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Georgetown University

Taichung Veterans General Hospital

Chung Shan Medical University

Tungchai University

Feng-Di Lung

C Richter King

Dajun Yang

Peter P Roller

Johannes H Voigt

Ya-Qui Long

Chi-Sheng Cheng

Ye-song Gu

Ya-Qiu Long

Man-Yee Chan

Jinghua Tsai Chang

Bor-rung Ou

The invention pertains to cancer treatment or prevention field. Particularly, the invention provides peptide fragments from SLIT2 protein and their applications in inhibition of cancer growth, invasion and metastasis.

Peptides for cancer treatment

The present application discloses a THLW peptide, an amino acid sequence of which is represented by SEQ ID No. 1. The THLW peptide can be used as a biomarker for diseases, such as oral cancer and cervical cancer, etc., relating to infection of human papilloma virus (HPV), therefore, THLW peptide as an antigen or an anti-THLW peptide antibody prepared can be used to detect the risk of developing cancer for sample providers.

Peptide, antibody thereof, and method of assessing risk of oral cancer by using peptide

This present invention provides a novel peptide for inhibiting growth of microorganisms, a pharmaceutical composition, an antimicrobial composition comprising such novel peptide, and a method for inhibiting growth of microorganisms. The novel peptide for inhibiting growth of microorganisms has amino acid sequence: KXLRXXXRRWX, wherein X, X, and Xare selected from the group of W and R, respectively; Xis selected from the group of V and P; and Xis selected from the group of R and methylated W. The method for inhibiting growth of microorganisms disclosed in this present invention comprises administering the novel peptide, the pharmaceutical composition, or the antimicrobial composition.

Peptide and uses thereof

Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use

A compound of formula:in which L is sulfur, sulfoxide, oxygen or methylene, and a compound of formula:in which (i) aais Adi and aais Glu or (ii) each of aaand aais Adi, L is sulfur, sulfoxide, oxygen or methylene, which compounds (and their conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, are non-phosphorylated, are redox-stable in vivo, are characterized by an ICin vivo of less than about 4.0 &#x3bc;M with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, have a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.

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Taichung, Taiwan

Feng-Di Lung