Cornell University

Memorial Sloan Kettering Cancer Center

University of Missouri

Feng Chen

Ulrich B Wiesner

Michelle S Bradbury

Kai Ma

Jason S Lewis

Thomas P Quinn

Snehal G Patel

Barney Yoo

Daniella Karassawa Zanoni

Brian Madajewski

Described herein are systems and methods for particle-based photodynamic therapy (PDT) for the treatment of diseases such as cancer of the oral cavity and/or ovarian cancer metastases along the lining of the pelvis. The technology includes an imaging system (e.g., a multichannel imaging camera) configured to perform diagnostic and/or therapeutic treatment on diseased tissue. In certain embodiments, the imaging system comprises one or more excitation sources (e.g., one or more lasers) to assess and/or treat diseased tissue.

Nanotherapeutic systems and methods using particle-driven photodynamic therapy (PDT)

Described herein are nanoprobes comprising ultrasmall aminated and cRGDY-conjugated nanoparticles labeled with Zirconium-89 (Zr) and methods of their use. The provided compositions are renally clearable and possess suitable blood circulation half-time, high tumor active targeting capability, dominant renal clearance, low liver accumulation, and a high tumor-to-background ratio. The described nanoprobes exhibit great potential as 'target-or-clear' tracers to human subjects for systemic targeted imaging (or treatment) of cancer.

Ultrasmall nanoparticles labeled with Zirconium-89 and methods thereof

Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

Nanoparticle immunoconjugates

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New York, NY, United States of America

Feng Chen