Bayer Intellectual Property Gmbh

Saltigo Gmbh

Bayer Cropscience Ag

Felix Rudolphi

Thomas Himmler

Lukas J Goossen

Matthias Gotta

Lukas J Gooβen

Alain Cotté

Bingrui Song

Christoph Oppel

Nuria Rodriguez Garrido

The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.

Process for preparing aryl- and heteroarylacetic acid derivatives

A process for preparing ketones of the general formula (III) where whereinn and m is a number in the range from 1 to 6,Mis a cation, andR has the meaning indicated for formula (III),with aryl bromides of the general formula (II)R&#x2014;Br&#x2003;&#x2003;(II)whereRhas the meaning indicated for formula (III),in the presence of two transition metals or compounds thereof as catalyst, is described.

Process for preparing ketones from alpha-oxo carboxylates and aryl bromides

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Schriesheim, Germany

Felix Rudolphi