Iceutica Pty Ltd.

Iceutica Py Ltd.

Iceutica Holdings Inc.

Felix Meiser

H William Bosch

Marck Norret

Adrian Russell

Aaron Dodd

Almar Postma

Raffaele Cammarano

Frank Caruso

Matthew Callahan

A method for producing a composition comprising nanoparticles of a biologically active compound.

Methods for the preparation of biologically active compounds in nanoparticulate form

The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments.

Formulation of indomethacin

Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 &#x3bc;m; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 &#x3bc;m and 20 &#x3bc;m are described.

Inhalable pharmaceutical compositions

The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.

Formulation of diclofenac

A method for producing a composition comprising nanoparticles of a biologically active compound, comprising the step of: dry milling a solid biologically active compound and a millable grinding compound in a mill comprising a plurality of milling bodies, for a time period sufficient to produce a solid dispersion comprising nanoparticles of the biologically active compound dispersed in an at least partially milled grinding compound is described as are various compositions produced using such methods.

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Claremont, Australia

Felix Meiser