Basf Se Corporation

Syntarga Bv

Georg-august-universitat Gottingen Stiftung Offentlichen Rechts

Felix Major

Otto Machhammer

Kerstin Schierle-Arndt

Stephan Maurer

Florian Garlichs

Michael Lutz

Patrick Henry Beusker

Jürgen Wortmann

Franciscus Marinus Hendrikus De Groot

Günther Huber

Lutz F Tietze

Henri Johannes Spijker

Johannes Albertus Frederikus Joosten

Guenther Huber

Juergen Wortmann

Fabian Seeler

Martin Gärtner

Martin Gaertner

Claus Schäfer

Claus Schaefer

The invention relates to a device for storing heat, comprising a heat storage medium which absorbs heat in order to store heat and releases heat in order to use the stored heat, and a container for holding the heat storage medium, the container being closed by a gastight cover, and the device comprising volume compensation means in order to compensate for a volume increase of the heat storage medium () due to a temperature rise and a volume decrease due to a temperature reduction. The invention furthermore relates to a method for storing heat, in which heat is transferred to a heat storage medium in order to store heat or heat is discharged from the heat storage medium to the heat carrier in order to use the heat, the heat storage medium being held in a container which is closed by a gastight cover, wherein a volume expansion of the heat storage medium () is compensated for by a volume increase of the container () or by heat storage medium () flowing out of the container () into a buffer container (), and a volume decrease of the heat storage medium () is compensated for by a volume decrease of the container () or by heat storage medium () flowing out of the buffer container () into the container ().

Device and method for storing heat

This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Water-soluble CC-1065 analogs and their conjugates

Growing community of inventors

Mannheim, Germany

Felix Major