Evonik Operations Gmbh

Evonik Roehm Gmbh

Felix Hofmann

Shraddha Joshi

Ashish Guha

Vinay Jain

Hans Bär

Bettina Hölzer

Marcel Arndt

Hans Baer

Silke Schminke

Julian Blaesy

Isabel Wahl

Miriam Robota

Vishal Kaneria

A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Process for preparing filled hard-shell capsules with cellulose or starch-based coatings with a capsule-filling machine

A process prepares a polymer-coated hard shell capsule, suitable as container for pharmaceutical or nutraceutical biologically active ingredients. The hard shell capsule can include a body and a cap. In the closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule can be provided in the pre-locked state and spray-coated with a coating solution, suspension, or dispersion that includes a polymer or a mixture of polymers to create a coating layer which covers the outer surface of the hard shell capsule in the pre-locked state.

Process for preparing a coated hard shell capsule

A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Process for preparing filled hard-shell capsules with (meth)acrylate copolymer based coatings with a capsule-filling machine

The invention refers to a Process for preparing a bio-resorbable polyester the form of a powder with a bulk density of 0.3 g/ml or more, a tapped density of 0.4 g/ml or more and a specific surface area of 2.0 m/g or less comprising the steps a. dissolving a bio-resorbable polyester in a first solvent to form a polymer solution, b. contacting the polymer solution with a second solvent which is a non-solvent for the bioresorbable polyester and which is mainly water to result the precipitation of the bio-resorbable polyester in the form of a wet polymer mass, c. pre-drying the wet polymer mass at a temperature below the Tof the bio-resorbable polyester, d. comminuting the pre-dried polymer mass to polymer particles with a size below 10 mm, e. drying the comminuted polymer particles below the Tof the bio-resorbable polyester to a residual water content of 1% or less by weight/weight, f. post-treatment of the polymer particles from step e at a temperature in the range from the Tto the Tof the bio-resorbable polyester, g. comminuting the polymer particles from step f to a powder with a particle size of dof 1-300 &#x3bc;m and dof more than 30 and up to 3000 &#x3bc;m.

Process for preparing a bio-resorbable polyester in the form of a powder

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Darmstadt, Germany

Felix Hofmann