Inhale Therapeutic Systems, Inc.

Nektar Therapeutics

Skinvestment, LLC

Pafra Limited

Felix Franks

Sheila Frances Mathias

Ross Henry Hatley

Anthony Auffret

William Mallow

Barry John Aldous

Barry Aldous

Ross H Hatley

Ross H M Hatley

Gloria Weissberg

Tina Alster

Sheila F Mathias

A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be stored at ambient temperature. Recovery is by adding aqueous solution to the composition.

Storage of materials

Materials which are not themselves storage-stable at room temperature are made suitable for storage by mixing them with a carrier substance and spray drying the resulting mixture so as to form particles containing both the material and the carrier substance in which the carrier substance is in an amorphous, i.e. glassy or rubbery, state. Formation of such a composition greatly enhances stability. The material stored may be a biological material such as an enzyme, the components of a chemical reaction such as reagents for carrying out an assay, or even viable biological cells.

In a composition which has an amorphous, undercooled, glassy phase containing a water-soluble or water-swellable substance in an amorphous form, a sugar, which is capable of existing as a crystalline hydrate, is used as an agent to dehydrate the amorphous phase by crystallisation therefrom, and thereby enhance the glass transition temperature of the residual amorphous phase.

Stable compositions

A face masque that applies cooling therapy to facial features of a patient. The masque is formed of two nylon or plastic layers that define a closed interior space and filled with a cooling medium that includes water, glycerin and hydroxyethyl cellulose. The masque controls the rate of heat dissipation from a user based upon the heat capacity, mass, rheology and composition of the materials used. The masque is lighter than conventional water-filled ice packs. It remains unfrozen and malleable even when cooled to sub-zero temperatures at which water-filled packs would freeze solid. The masque readily conforms to facial features due to the materials used, thereby contributing to improved comfort on the part of a user. Further, the masque possesses improved cooling therapy because it remains cold for longer periods of time relative to water-filled ice packs. Optionally, the masque accommodates eye inserts placed between a main body of the masque and recesses of the patient's eyes. Also, the masque may be provided with a cloth sheath separating the nylon or plastic layers from the patient's face.

Therapeutic face and eye masque

In a composition which has an amorphous, undercooled, glassy phase containing a water-soluble or water-swellable substance in an amorphous form, a sugar, which is capable of existing as a crystalline hydrate, is used as an agent to dehydrate the amorphous phase by crystallization therefrom, and thereby enhance the glass transition temperature of the residual amorphous phase.

Process for storage of materials

Growing community of inventors

Cambridge, United Kingdom

Felix Franks