Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Icahn School of Medicine at Mount Sinai

Felix Bröcker

Adolfo Garcia-Sastre

Peter H Seeberger

Claney Lebev Pereira

Florian Krammer

Chakkumkal Anish

Sharavathi Guddehalli Parameswarappa

Dominea Rathwell

Peter Palese

Subramanian Govindan

Weina Sun

In one aspect, provided herein is a mosaic influenza virus hemagglutinin (HA) polypeptide comprising an influenza A virus HA ectodomain of an influenza A virus strain HA, wherein the HA ectodomain comprises an HA stem domain of the influenza A virus strain HA and an HA globular head domain of the influenza A virus strain HA, wherein the HA globular head domain of the influenza A virus strain HA has been engineered to comprise one or more amino acid substitutions in one, two, three, four or all of the antigenic sites. In another aspect, provided herein are immunogenic compositions comprising such a mosaic influenza virus HA polypeptide or an influenza A virus comprising such a mosaic influenza virus HA polypeptide. In yet another aspect, provided herein are methods for immunizing a subject against an influenza A virus in a subject comprising administering such an immunogenic composition to the subject.

Mosaic influenza virus hemagglutinin polypeptides and uses thereof

The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is atype 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with, and more specifically against diseases associated withtype 3.

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Berlin, Germany

Felix Bröcker