Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Felix Broecker

Peter H Seeberger

Chakkumkal Anish

Christopher E Martin

The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of theglycopolymer PS-I: &#x3b1;--Rhap-(1&#x2192;3)-&#x3b2;--Glcp-(1&#x2192;4)-[&#x3b1;--Rhap-(1&#x2192;3)]-&#x3b1;--Glcp-(1&#x2192;2)-&#x3b1;--Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by. The present invention further pertains to a method of treating or preventing a disease caused by the pathogen, which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.

Antibodies for prevention and treatment of diseases caused by clostridium difficile

The invention relates to a synthetic oligosaccharide representing part of the repeating unit of theglycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap-(1&#x2192;3)-&#x3b2;-D-Glcp-(1&#x2192;4)-[a-L-Rhap-(1&#x2192;3]-a-D-Glcp-(1&#x2192;2)-a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.

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Berlin, Germany

Felix Broecker