Fundacion Para La Investigacion Medica Aplicada

Universidad De Navarra

Leartiker, S.coop.

Felipe Prósper Cardoso

Julen Oyarzabal Santamarina

Maria Obdulia Rabal Gracia

Edurne San José Enériz

Xabier Aguirre Ena

Juan Antonio Sánchez Arias

Juan Roberto Rodríguez Madoz

Pablo Larreategi Makatzaga

Enrique José AndreÚ Oltra

Ane Miren Zaldua Huici

It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein A, R, R, and Rare as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation. 

Compounds as inhibitors of DNA methyltransferases

It relates to the use of compounds of formula (I'), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I&#x2032;), wherein R&#x2032; is an alcoxy group, a hydrocarbon chain or a ring system, and R, R, and Rare as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I&#x2032;), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R&#x2032; is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I). 

Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases

Growing community of inventors

Pamplona, Spain

Felipe Prósper Cardoso