United States of America, as Represented by the Secretary of Agriculture

Louisiana State University and Agricultural & Mechanical College

Washington State University

Felicito Guerrero

Adalberto A Perez De Leon

Luisa N Domingues

Robert A Miller

Robert E Briggs

Fred M Tatum

Lane D Foil

Glen A Scoles

Reginaldo Bastos

Kylie G Bendele

Alicja Tabor

Matthew Bellgard

Manuel Rodriguez Valle

Andrew Y Li

The invention relates to antigenic polypeptides derived from a naturally occurringprotein, and nucleic acids encoding such polypeptides. The polypeptides elicit an immune response which, in turn, produces detrimental effects infeeding on vaccinated cattle. Thus, the present disclosure provides novel vaccines to protect cattle frominfestation.

Cattle fever tick-infestation vaccines and uses thereof

This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.

Southern cattle tick vaccine product

Antigenic polypeptides derived from a naturally occurring horn fly protein, and nucleic acid molecules encoding the polypeptides, are described. The polypeptides elicit an immune response which, in turn, produces detrimental effects in horn flies feeding on vaccinated cattle. Thus, the present disclosure provides a novel horn fly vaccine.

Horn fly protein as active antigen in anti-horn fly vaccine for protection of bovines against horn fly infestations

The present invention relates to immunogenic polypeptides, immunogenic fragments thereof and compositions comprising same, for use in eliciting an immune response in a subject to a tick. The invention also provides for methods of using said compositions and polypeptides.

Immunostimulating compositions and uses therefore

A novel method of using an aquaporin protein from(RmAQP2), fragments of RmAQP2, and/or the cDNA encoding RmAQP2 and/or the fragments are described. Immunogenic composition containing recombinant RmAQP2 and/or fragments of RmAQP2 are produced and administered to an ungulate which generates an immune response to RmAQP2. After feeding female ticks on the ungulate injected with RmAQP2 and/or fragments of RmAQP2, the female ticks have lower reproductive viability because of a reduced egg mass, reduced hatching percentage, and reduced survival of larvae. Thus, administering RmAQP2 and/or RmAQP2 fragments to an ungulate can reduce the incidence ofand also reduce the incidence of tick-borne pathogens in ungulates because of the lower number of

Aquaporin 2 protects cattle from ticks and tick-borne parasites

Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick,, or a nucleic acid construct incorporating a nucleic acid sequence encoding this Rm86Texas protein, are effective for eliciting a protective immune response in non-bovine animals. The Rm86Texas protein is immunogenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks. Moreover, as ticks are vectors of a variety of pathogens, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogens in susceptible animals.

Vaccination with anti-tick antigens to control multiple tick species and disease transmission in white-tailed deer and other host animals

Two antigenic and immunogenic proteins of the cattle tick,, and the genes encoding these proteins, are effective for eliciting a protective immune response that controls and prevents infestations of bovines and other livestock by the tick. The proteins isolated from the cattle tick include an aquaporin protein and a TC5777 gut membrane protein. Each of the proteins elicit an immunoprotective response in livestock to the cattle tick, and can be formulated and administered as vaccines. Alternatively, the isolated DNA sequences which encode these proteins can be incorporated into nucleic acid constructs which could be utilized as DNA vaccines. The nucleic acid constructs can also be used for the transformation of cells and the production of recombinant proteins. Induction of the protective immune response controls and prevents infestations of the treated animals with the tick, thereby protecting them against tick-borne pathogen transmission.

Vaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission

Compositions of either the aquaporin protein from the cattle tick,, or a nucleic acid construct incorporating a nucleic acid sequence encoding this aquaporin protein, are effective for eliciting a protective immune response against other tick species in non-bovine animals. Theaquaporin protein is antigenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks other than the cattle tick, particularly the brown dog tick,. Moreover, as ticks are vectors of a variety of pathogenic agents, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogenic agents in susceptible animals.

Growing community of inventors

Boerne, TX, United States of America

Felicito Guerrero