Cornell Research Foundation Inc.

Felice Scala

Gary E Harman

Matteo Lorito

Christopher K Hayes

Antonio Di Pietro

Christian P Kubicek

A system for inhibiting the germination or growth of a fungus comprises (a) fungal cell wall degrading chitinolytic or glucanolytic enzyme and (b) antifungal cell membrane affecting: compound. Exemplified antifungal fungal cell membrane affecting compounds include flusilazole, miconazole, osmotin, gramicidin, valinomycin, phospholipase B, and trichorzianines. The system components (a) and (b) may be supplemented with polyene macrolide antibiotic, antifungal epithiodiketopiperazine antibiotic (e.g., gliotoxin), fungal cell wall biosynthesis inhibitor (e.g., L-sorbose) and/or detergent. Embodiments include method of contacting a plant which expresses cell wall degrading enzyme with antifungal fungal cell membrane affecting compound.

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Sorrento, Italy

Felice Scala