Lawrence Livermore National Security, LLC

Merck Sharp + Dohme Corp.

Felice C Lightstone

Sergio E Wong

John M Finn

Xiaoming Li

Junhu Zhang

Zhiyong Chen

Leslie William Tari

Thanh To Lam

Michael Trzoss

Suk Joong Lee

Daniel Bensen

Toan B Nguyen

Michael E Jung

Douglas W Phillipson

Min Teng

Joe H Satcher, Jr

Roger D Aines

Carlos A Valdez

Allen Borchardt

Paul Aristoff

Sarah Elyse Baker

John F Finn

Joshuah K Stolaroff

Edmond Y Lau

Voon Ong

Heather Ann Enright

Brian J Bennion

Tuan H Nguyen

Nicholas A Be

Margaret Windy McNerney

Tim Carpenter

Mike Malfatti

Allen John Borchardt

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic Gyrase inhibitors

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic gyrase inhibitors

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

The creation of a catalyst that can be used for a wide variety of applications including the steps of developing preliminary information regarding the catalyst, using the preliminary information to produce a template of the catalyst, and using the template of the catalyst to produce the catalyst.

[object Object]

A system is provided that substantially increases the efficiency of COcapture and removal by positioning a catalyst within an optimal distance from the air-liquid interface. The catalyst is positioned within the layer determined to be the highest concentration of carbon dioxide. A hydrophobic tether is attached to the catalyst and the hydrophobic tether modulates the position of the catalyst within the liquid layer containing the highest concentration of carbon dioxide.

Tethered catalysts for the hydration of carbon dioxide

Growing community of inventors

Fremont, CA, United States of America

Felice C Lightstone