Chinese Academy of Sciences

Suzhou Vigonvita Life Sciences Co., Ltd.

Topharman Shanghai Co., Ltd.

Topharman Shandong Co., Ltd.

Feipu Yang

Yu Ying Wang

Hualiang Jiang

Zhen Wang

Yang He

Jingshan Shen

Jianfeng Li

Guanghui Tian

Rongxia Zhang

Xiangrui Jiang

Weiming Chen

Yongjian Liu

Zheng Liu

Guan Zhong Wang

Chunhui Wu

Jin Suo

Minghao Bi

Jingjing Yin

Yu Wang

The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation. 

Maleate salt of benzothiophene compound, crystalline form thereof, and use thereof

The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease. 

Heterocyclic compounds, process for preparation of the same and use thereof

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Shanghai, China

Feipu Yang