Astrazeneca Ab

Entasis Therapeutics, Inc.

Fei Zhou

Gregory Steven Basarab

Sheila Irene Hauck

Madhusudhan Reddy Gowravaram

Michael Barry Gravestock

Neil James Hales

Folkert Reck

Paul Robert Fleming

Brian A Sherer

Daniel Robert Carcanague

Pamela Hill

Kevin Barvian

Kenneth Gregory Hull

George Byron Mullen

Oluyinka Morenike Green

Haihong Ni

Brian Dangel

Marc Michel Girardot

Greg Basarab

Gregory Basarab

Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed. 

Compounds and methods for treating bacterial infections

The present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.

Chemical compounds 542

The present invention relates to compounds of Formula (I); to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation. 

Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. 

Antibacterial piperdine derivatives

Piperidine compounds for use in the treatment of bacterial infections

A compound of the formula (I), or a pharmaceutically-acceptable salt, or in-vivo hydrolysable ester thereof: Wherein C is selected from (D) and (E), Ra, Ra, and Ra are independently selected from for example H, CF, Me and Et; Rb and R6b are independently selected from for example H, F, CF, Me and Et; Rb is for example optionally substituted diazolyl, triazolyl or tetrazolyl; Ris for example an optionally substituted 5- or 6-membered heterocyclic ring system. Methods for making compounds of the formula (I), compositions containing them and their use as antibacterial agents are also described. 

Oxazolidinones as antibacterial agents

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein &#x2014;N-HET is, for example, (Ic) or (If) wherein R1 is (1-4C)alkyl; wherein Rand Rare independently hydrogen or fluoro; wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein &#x2014;N-HET is, for example, (Ic) or (If) wherein R1 is, for example, halogen or a (1&#x2013;4C)alkyl group which is substituted by one substituent selected from, for example, hydroxy, (1&#x2013;4C)alkoxy, amino, cyano or azido; Q is selected from, for example, Q1 wherein Rand Rare independently hydrogen or fluoro;T is selected from a range of groups, for example, wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

Chemical compounds

Growing community of inventors

Waltham, MA, United States of America

Fei Zhou